I get this error every time i start up the bot. i am running wow at 32bit i start wow up first then the bot, and tried running it as admin for both.
Something wrong with your .net. Try this: http://www.thebuddyforum.com/releases/68254-problems-new-install-buddy-product.html
Nope - I have it running on both 32/64 Win7 and Win8 with no issues. That error means that it is having trouble accessing some of .NET 4's resources. I'd recommend uninstalling .NET 4 and reinstalling it - seems like something is amiss with your installation of it.